利妥昔单抗似乎是治疗伴有肠道穿孔的肉芽肿性多血管炎的一种有前景的治疗选择：一例病例报告及文献综述
Rituximab seems a promising therapeutic option in granulomatosis with polyangiitis with intestinal perforation: a case report and literature review.
作者信息
Dag Muhammet Sait, Pehlivan Yavuz, Tutar Ediz, Kisacik Bunyamin
机构信息
Department of Gastroenterology, Gaziantep University, School of Medicine, Sahinbey Medical Center, Gaziantep, Turkey.
出版信息
BMJ Case Rep. 2013 Jan 22;2013:bcr2012007518. doi: 10.1136/bcr-2012-007518.
Abstract
Granulomatosis with polyangiitis (Wegener's) (GPA) is a chronic disease of unknown aetiology that leads to necrotising vasculitis in small and medium-sized vessels characterised by respiratory system and kidney involvement. Intestinal involvement is rare and perforation is even rarer in GPA. In this study, we are presenting a literature review of related cases, and a 29-year-old man referred from the emergency department with a multiple distal ileal perforation that was diagnosed with GPA, and successfully treated with rituximab.
摘要
肉芽肿性多血管炎（韦格纳氏）（GPA）是一种病因不明的慢性疾病，可导致中小血管的坏死性血管炎，其特征为累及呼吸系统和肾脏。GPA累及肠道罕见，发生穿孔则更为罕见。在本研究中，我们对相关病例进行了文献综述，并报告了一名29岁男性患者，该患者从急诊科转诊而来，因回肠末端多处穿孔被诊断为GPA，并通过利妥昔单抗成功治愈。
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