Dag Muhammet Sait, Pehlivan Yavuz, Tutar Ediz, Kisacik Bunyamin
Department of Gastroenterology, Gaziantep University, School of Medicine, Sahinbey Medical Center, Gaziantep, Turkey.
BMJ Case Rep. 2013 Jan 22;2013:bcr2012007518. doi: 10.1136/bcr-2012-007518.
Granulomatosis with polyangiitis (Wegener's) (GPA) is a chronic disease of unknown aetiology that leads to necrotising vasculitis in small and medium-sized vessels characterised by respiratory system and kidney involvement. Intestinal involvement is rare and perforation is even rarer in GPA. In this study, we are presenting a literature review of related cases, and a 29-year-old man referred from the emergency department with a multiple distal ileal perforation that was diagnosed with GPA, and successfully treated with rituximab.
肉芽肿性多血管炎（韦格纳氏）（GPA）是一种病因不明的慢性疾病，可导致中小血管的坏死性血管炎，其特征为累及呼吸系统和肾脏。GPA累及肠道罕见，发生穿孔则更为罕见。在本研究中，我们对相关病例进行了文献综述，并报告了一名29岁男性患者，该患者从急诊科转诊而来，因回肠末端多处穿孔被诊断为GPA，并通过利妥昔单抗成功治愈。
