Geraghty J, Mackay I R, Smith D C
Gut. 1986 Apr;27(4):450-1. doi: 10.1136/gut.27.4.450.
Wegener's granulomatosis is a disease characterised by a necrotising vasculitis and granulomatous inflammation. The localised form involves the upper and/or lower respiratory tracts while in the commoner generalised form there is a widespread necrotising vasculitis and renal involvement. Intestinal involvement, which may be severe, has been detected at necropsy in 24% of cases. Gastrointestinal symptoms are uncommon, however, none being mentioned in a recent series of 87 cases. There has been only one reported case of intestinal perforation secondary to Wegener's granulomatosis. We report a case of small and large bowel perforations in a patient with Wegener's granulomatosis.
韦格纳肉芽肿病是一种以坏死性血管炎和肉芽肿性炎症为特征的疾病。局限性形式累及上呼吸道和/或下呼吸道，而较常见的全身性形式则存在广泛的坏死性血管炎和肾脏受累。尸检发现24%的病例存在肠道受累，且可能较为严重。然而，胃肠道症状并不常见，在最近一组87例病例中均未提及。仅有1例继发于韦格纳肉芽肿病的肠道穿孔报告。我们报告1例韦格纳肉芽肿病患者发生小肠和大肠穿孔的病例。
