Fradet G, Smyth R L, Scott J P, Solis E, Sharples L, Higenbottam T W, Wallwork J
Department of Transplantation Surgery, Papworth Hospital, Cambridgeshire, UK.
Eur J Cardiothorac Surg. 1990;4(3):136-40; discussion 140-1. doi: 10.1016/1010-7940(90)90184-2.
Cystic fibrosis (CF) is the most common fatal inherited disease in caucasian populations. Between 80-120 CF patients die each year in England and Wales, the majority from pulmonary disease. Since October 1985, 17 patients with CF have undergone heart-lung transplantation (HLT) at our institution. Only 3 early deaths have occurred in the first 2 postoperative months. Another patient died 9 months after transplantation. Thirteen patients are now alive 1-46 months (mean 14 month) post transplantation. Actuarial survival at 6 months is 80% for CF patients compared to 73% for non-CF patients. Both groups of patients have similar profiles of rejection and infection. In the Caucasian population, CF patients form the largest potential recipient group for HLT and our experience suggests that those CF patients who undergo HLT have a favourable outcome.
囊性纤维化（CF）是白种人群中最常见的致命性遗传疾病。在英格兰和威尔士，每年有80至120名CF患者死亡，大多数死于肺部疾病。自1985年10月以来，我院有17例CF患者接受了心肺移植（HLT）。术后头2个月仅发生3例早期死亡。另有1例患者在移植后9个月死亡。目前有13例患者在移植后1至46个月（平均14个月）存活。CF患者6个月时的精算生存率为80%，非CF患者为73%。两组患者的排斥反应和感染情况相似。在白种人群中，CF患者是HLT最大的潜在受者群体，我们的经验表明，接受HLT的CF患者预后良好。
