Cartling B
Department of Theoretical Physics, Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
J Biol Phys. 2000 Jun;26(2):113-31. doi: 10.1023/A:1005223902152.
Stochastic and reduced biophysical models of synaptictransmission are formulated and evaluated. Thesynaptic transmission involves presynapticfacilitation of neurotransmitter release, depletionand recovery of the presynaptic pool of readilyreleasable vesicles containing neurotransmittermolecules and saturation of postsynaptic receptors ofboth fast non-NMDA and slow NMDA types. The models areshown to display the principal dynamicalcharacteristics experimentally observed of synaptictransmission. The two main types of neural coding,i.e. rate and temporal coding, can be distinguished bymeans of different dynamical properties of synaptictransmission determined by initial neurotransmitterrelease probability and presynaptic firing rate. Fromthe temporal evolution of the postsynaptic membranepotential response to a train of presynaptic actionpotentials at a sustained firing rate, in particularthe steady-state amplitude and steady-state averagelevel of postsynaptic membrane potentials aredetermined as functions of both initial releaseprobability and presynaptic firing rate. The modelsare applicable to studies of the primary stages oflearning processes and can be extended to incorporateshort-term and long-term potentiation in memoryconsolidation processes.
建立并评估了突触传递的随机和简化生物物理模型。突触传递涉及神经递质释放的突触前易化、含有神经递质分子的突触前易释放囊泡池的消耗和恢复，以及快速非NMDA型和慢速NMDA型突触后受体的饱和。这些模型被证明展示了实验观察到的突触传递的主要动力学特征。两种主要的神经编码类型，即速率编码和时间编码，可以通过由初始神经递质释放概率和突触前发放率决定的突触传递的不同动力学特性来区分。从突触后膜电位对以持续发放率的一串突触前动作电位的时间演化中，特别是突触后膜电位的稳态幅度和稳态平均水平被确定为初始释放概率和突触前发放率的函数。这些模型适用于学习过程初级阶段的研究，并且可以扩展以纳入记忆巩固过程中的短期和长期增强。
