Cartling Bo
Department of Physics, Division of Biological Physics, Royal Institute of Technology, SE-106 91 Stockholm, Sweden.
J Biol Phys. 2004 Sep;30(3):261-84. doi: 10.1023/B:JOBP.0000046745.65807.5e.
A biophysical model of a neocortical microcircuit system is formulated and employed in studies of neuromodulatory control of dynamics and function. The model is based on recent observations of reciprocal connections between pyramidal cells and inhibitory interneurons and incorporates a new type of activity-dependent short-term depression of synaptic couplings recently observed. The model neurons are of a low-dimensional type also accounting for neuronal adaptation, i.e. the coupling between neuronal activity and excitability, which can be regulated by various neuromodulators in the brain. The results obtained demonstrate a capacity for neuromodulatory control of dynamical mode linked to functional mode. The functional aspects considered refer to the observed resolution of multiple objects in working memory as well as the binding of different features for the perception of an object. The effects of neuromodulators displayed by the model are in accordance with many observations on neuromodulatory influence on cognitive functions and brain disorders.
一个新皮层微电路系统的生物物理模型被构建并用于研究动力学和功能的神经调节控制。该模型基于最近对锥体细胞和抑制性中间神经元之间相互连接的观察，并纳入了最近观察到的一种新型的依赖活动的突触耦合短期抑制。模型神经元是低维类型的，也考虑了神经元适应性，即神经元活动与兴奋性之间的耦合，这可以由大脑中的各种神经调节剂调节。所获得的结果证明了神经调节对与功能模式相关的动力学模式的控制能力。所考虑的功能方面涉及工作记忆中多个物体的观察分辨率以及物体感知中不同特征的绑定。该模型显示的神经调节剂的作用与许多关于神经调节对认知功能和脑部疾病影响的观察结果一致。
