Lipowsky Reinhard
Max-Planck-Institute of Colloids and Interfaces, 14424 Potsdam, Germany.
J Biol Phys. 2002 Jun;28(2):195-210. doi: 10.1023/A:1019994628793.
Both biomembranes and biomimetic membranes such as lipid bilayers withseveral components contain intramembrane domains and rafts.Macromolecules, which are anchored to the membrane but have no tendeney tocluster, induce curved nanodomains. Clustering of membrane componentsleads to larger domains which can grow up to a certain maximal size andthen undergo a budding process. The maximal domain size depends on theinterplay of spontaneous curvature, bending rigidity, and line tension.It is argued that this interplay governs the formation of bothclathrin-coated buds and caveolae. Finally, membrane adhesion often leadsto domain formation within the contact zone.
生物膜和仿生膜（如含有多种成分的脂质双层膜）都包含膜内结构域和筏。锚定在膜上但没有聚集倾向的大分子会诱导形成弯曲的纳米结构域。膜成分的聚集会导致形成更大的结构域，这些结构域可以生长到一定的最大尺寸，然后经历出芽过程。最大结构域尺寸取决于自发曲率、弯曲刚度和线张力之间的相互作用。有人认为这种相互作用控制着网格蛋白包被小泡和小窝的形成。最后，膜黏附通常会导致接触区内形成结构域。
