Walker G C, Berry E, Smye S W, Zinov'ev N N, Fitzgerald A J, Miles R E, Chamberlain M, Smith M A
Academic Unit of Medical Physics, University of Leeds, UK.
J Biol Phys. 2003 Jun;29(2-3):141-8. doi: 10.1023/A:1024484523964.
Modelling the interaction of terahertz(THz) radiation with biological tissueposes many interesting problems. THzradiation is neither obviously described byan electric field distribution or anensemble of photons and biological tissueis an inhomogeneous medium with anelectronic permittivity that is bothspatially and frequency dependent making ita complex system to model.A three-layer system of parallel-sidedslabs has been used as the system throughwhich the passage of THz radiation has beensimulated. Two modelling approaches havebeen developed a thin film matrix model anda Monte Carlo model. The source data foreach of these methods, taken at the sametime as the data recorded to experimentallyverify them, was a THz spectrum that hadpassed though air only.Experimental verification of these twomodels was carried out using athree-layered in vitro phantom. Simulatedtransmission spectrum data was compared toexperimental transmission spectrum datafirst to determine and then to compare theaccuracy of the two methods. Goodagreement was found, with typical resultshaving a correlation coefficient of 0.90for the thin film matrix model and 0.78 forthe Monte Carlo model over the full THzspectrum. Further work is underway toimprove the models above 1 THz.
对太赫兹（THz）辐射与生物组织的相互作用进行建模会带来许多有趣的问题。太赫兹辐射既不能明显地用电场分布或光子集合来描述，而且生物组织是一种不均匀介质，其介电常数在空间和频率上都有依赖性，这使得它成为一个难以建模的复杂系统。一个由平行平板组成的三层系统已被用作模拟太赫兹辐射通过过程的系统。已经开发了两种建模方法，即薄膜矩阵模型和蒙特卡罗模型。这两种方法的源数据，是在与用于实验验证它们而记录的数据同时获取的，是仅通过空气的太赫兹光谱。
使用三层体外模型对这两种模型进行了实验验证。首先将模拟传输光谱数据与实验传输光谱数据进行比较，以确定然后比较这两种方法的准确性。结果发现二者吻合良好，在整个太赫兹光谱范围内，典型结果的薄膜矩阵模型相关系数为0.90，蒙特卡罗模型相关系数为0.78。目前正在开展进一步工作以改进高于1太赫兹频段的模型。
