Matsson Leif, Sa-Yakanit Virulh, Boribarn Santipong
Department of Physics, Condensed Matter Theory Division, Göteborg University, SE-41296 Gothenburg, Sweden.
J Biol Phys. 2005 Dec;31(3-4):525-32. doi: 10.1007/s10867-005-4807-z.
Trans-membrane currents in ligand-gated ion channels are calculated in a non-equilibrium, chemically open whole cell system. The model is lyotropic in the sense that dynamics and parameters such as ligand concentration for half-maximal response (scale of response), and threshold for firing in neurons, are nonlinear functions of the reactant concentrations. The derived total current fits recorded data significantly better than those derived from mass action, Ising, and other equilibrium type models, in which the derived response can be displaced from the assessed response by several orders in the ligand concentration. A comparison of the model obtained with an Ising-like model provides a methodology to obtain the non-equilibrium scaling dependence of Ising-like models on the reactant concentrations.
在非平衡、化学开放的全细胞系统中计算配体门控离子通道中的跨膜电流。该模型是离液序列高的，即动力学和参数，如半数最大反应的配体浓度（反应尺度）以及神经元放电阈值，是反应物浓度的非线性函数。所推导的总电流比从质量作用、伊辛模型和其他平衡型模型推导的电流能更好地拟合记录数据，在这些平衡型模型中，推导的反应在配体浓度上可能与评估的反应相差几个数量级。将所得模型与类伊辛模型进行比较，提供了一种获得类伊辛模型对反应物浓度的非平衡标度依赖性的方法。
