DNA动力学与复制模型。
Model of DNA dynamics and replication.
作者信息
Matsson Leif
机构信息
Department of Physics, Condensed Matter Theory Division, Göteborg University, S-412 96 Göteborg, Sweden.
出版信息
J Biol Phys. 2005 Dec;31(3-4):303-21. doi: 10.1007/s10867-005-4635-1.
Before DNA replication can be initiated a definite number of adenosine triphosphate (ATP) containing pre-replication protein complexes (pre-RCs) must be assembled and bound to DNA like in a super-critical mass. A chemically driven dynamics of the Ginzburg-Landau (GL) type is derived, using the non-equilibrium equation for binding of pre-RCs to DNA and a probabilistic conformational distribution of these protein complexes. This dynamics, in which the DNA-protein system behaves like a nonlinear elastically braced string (NEBS), can control the cell cycle via conformational transitions such that G(2) cells contain exactly twice as much DNA as G(1) cells. After adjustment of previously-made derivations, the model is compared with cell growth data from the T lymphocyte MLA-144.
在DNA复制开始之前，必须组装一定数量含三磷酸腺苷（ATP）的预复制蛋白复合物（pre-RCs），并使其像处于超临界质量状态那样与DNA结合。利用pre-RCs与DNA结合的非平衡方程以及这些蛋白复合物的概率构象分布，推导了一种金兹堡 - 朗道（GL）型的化学驱动动力学。在这种动力学中，DNA - 蛋白质系统的行为类似于非线性弹性支撑弦（NEBS），它可以通过构象转变来控制细胞周期，使得G2期细胞的DNA含量恰好是G1期细胞的两倍。在对之前的推导进行调整后，将该模型与T淋巴细胞MLA - 144的细胞生长数据进行了比较。
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