Kuhn Christoph
Institute für Molekularbiologie und Biophysik, Gruppe Biophysik, ETH-Hönggerberg, CH 8093 Zürich, Switzerland.
J Biol Phys. 2005 Dec;31(3-4):571-85. doi: 10.1007/s10867-005-6163-4.
Evolution is assumed to begin in a very particular compartmentalized location with periodic conditions. A highly diversified world is the driving force for the continuous increase in complexity by colonizing increasingly less favourable regions. Modeling the "origin-of-life" a Darwinian cyclic process is simulated (multiplication with sporadic errors followed by a construction and selection).Starting from a RNA-world (R-strands of R(1) and R(2) monomers building Hairpin-Assembler devices) and introducing another kind of monomers (A(1) and A(2) which interlink to the Hairpin-Assembler devices such that they become bound and form an A-oligomer) it is shown that a simple translation apparatus evolves producing enzymes (specific sequences of A(1) and A(2) monomers given by the sequences of R(1) and R(2) monomers on the assembler-strands). Later on D-strands are introduced, which are not capable of participating in the synthesis of A-oligomers. These D-strands become carriers of the genetic information and induce the formation of increasingly complex entities of functionally interplaying components.
进化被认为始于一个具有周期性条件的非常特殊的分隔区域。一个高度多样化的世界是通过殖民越来越不利的区域来推动复杂性不断增加的驱动力。对“生命起源”进行建模,模拟了一个达尔文循环过程(带有偶发错误的增殖,随后是构建和选择)。从RNA世界(由R(1)和R(2)单体的R链构建发夹组装装置)开始,并引入另一种单体(A(1)和A(2),它们与发夹组装装置相互连接,从而结合在一起形成A寡聚物),结果表明,一种简单的翻译装置进化产生了酶(由组装链上R(1)和R(2)单体的序列给出的A(1)和A(2)单体的特定序列)。后来引入了D链,它们不能参与A寡聚物的合成。这些D链成为遗传信息的载体,并诱导形成功能上相互作用的成分越来越复杂的实体。