Jamema Swamidas, Mahantshetty Umesh, Deshpande Dd, Sharma Smriti, Shrivastava Sk
Department of Medical Physics, Tata Memorial Hospital, Mumbai, India.
J Contemp Brachytherapy. 2011 Sep;3(3):142-9. doi: 10.5114/jcb.2011.24821. Epub 2011 Sep 30.
To report our experience of dosimetric comparison of IPSA and manual plans, with a focus on the use of help structures (HS) during optimization.
33 patients who underwent MR image-based HDR intracavitary-brachytherapy for cervix cancer based on GYN-ESTRO recommendations were selected for evaluation. Tandem/ovoid (T/O) and Vienna applicators were used. HS of diameter of 5 mm were drawn around the tandem/needles/ovoid and ring. Three plans were generated: manual optimized plan (MOPT), IPSA without help structures (IPSA_woHS) and IPSA with help structures (IPSA_wHS). Dose-volume parameters and the loading pattern were evaluated.
For T/O, the use of HS did not make significant impact in the dose-volume parameters and in the loading of tandem and ovoids, however steep variation was found in the individual dwell time. In case of Vienna applicator, inclusion of HS in the optimization made a significant impact in loading of needles. The percentage ratio of total time of needles to the tandem (T(N/T%)) was found to be 14±2.5, 53±9, 22±6 for MOPT, IPSA_woHS and IPSA_wHS, respectively, which implies that in IPSA_woHS the dwell time in needles were half of the dwell time in the tandem, while in MOPT the needles were loaded only in 14%, and in IPSA_wHS it was 22% of the dwell time of tandem. Inclusion of HS in the optimization has reduced the contribution of dwell time of needle in IPSA_wHS. The individual variation of dwell time was also reduced in IPSA_wHS, however drawing of HS is a time consuming procedure and may not be practical for a routine practice.
The role of HS was evaluated for IPSA for T/O and Vienna-applicator, the use of HS may be beneficial in case of combined intracavitary - interstitial approach.
报告我们对IPSA计划和手动计划进行剂量学比较的经验,重点关注优化过程中辅助结构(HS)的使用。
选取33例根据GYN-ESTRO建议接受基于磁共振图像的宫颈癌高剂量率腔内近距离治疗的患者进行评估。使用了串联/卵圆体(T/O)和维也纳施源器。在串联/针/卵圆体和环周围绘制直径为5mm的辅助结构。生成了三个计划:手动优化计划(MOPT)、无辅助结构的IPSA计划(IPSA_woHS)和有辅助结构的IPSA计划(IPSA_wHS)。评估了剂量体积参数和加载模式。
对于T/O,辅助结构的使用对剂量体积参数以及串联和卵圆体的加载没有显著影响,然而在单个驻留时间上发现了急剧变化。对于维也纳施源器,在优化过程中纳入辅助结构对针的加载有显著影响。MOPT、IPSA_woHS和IPSA_wHS的针总时间与串联时间的百分比(T(N/T%))分别为14±2.5、53±9、22±6,这意味着在IPSA_woHS中针的驻留时间是串联驻留时间的一半,而在MOPT中针仅加载14%的时间,在IPSA_wHS中是串联驻留时间的22%。在优化过程中纳入辅助结构减少了IPSA_wHS中针驻留时间的贡献。IPSA_wHS中驻留时间的个体差异也有所减少,然而绘制辅助结构是一个耗时的过程,对于常规实践可能不实用。
评估了辅助结构在IPSA用于T/O和维也纳施源器时的作用,在腔内 - 组织间联合治疗方法中使用辅助结构可能是有益的。