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载蛋白微球的同轴或乳液电喷射制备的控释行为。

Controlled release behaviour of protein-loaded microparticles prepared via coaxial or emulsion electrospray.

机构信息

Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China.

出版信息

J Microencapsul. 2013;30(5):490-7. doi: 10.3109/02652048.2012.752537. Epub 2013 Jan 25.

DOI:10.3109/02652048.2012.752537
PMID:23346923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3709885/
Abstract

Biodegradable poly (lactic-co-glycolic acid) (PLGA) microparticles are an effective way to achieve sustained drug release. In this study, we investigated a sustained release model of PLGA microparticles with incorporated protein via either emulsion or coaxial electrospray techniques. PLGA (75:25) was used as the carrier, and bovine serum albumin as a model protein. Coaxial electrospray resulted in a type of core-shell structure with mean diameters of 2.41 ± 0.60 µm and a centralised protein distribution within the core. Emulsion electrospray formed bigger microparticles with mean diameters of 22.75 ± 8.05 µm and a heterogeneous protein distribution throughout the microparticles. The coaxial electrospray microparticles presented a much slighter burst release than the emulsion electrospray microparticles. Loading efficiency was significantly higher (p < 0.05) in the coaxial group than emulsion group. This indicated that both emulsion and coaxial electrospray could produce protein-loaded microparticles with sustained release behaviour, but the former revealed a superior approach for drug delivery.

摘要

可生物降解的聚（乳酸-共-乙醇酸）（PLGA）微球是实现药物持续释放的有效方法。在这项研究中，我们通过乳化或同轴静电喷雾技术研究了包载蛋白质的 PLGA 微球的持续释放模型。PLGA（75:25）用作载体，牛血清白蛋白作为模型蛋白。同轴静电喷雾产生一种具有 2.41±0.60μm 平均直径和中央蛋白分布的核壳结构。乳化静电喷雾形成更大的微球，平均直径为 22.75±8.05μm，且蛋白在整个微球中分布不均匀。同轴静电喷雾微球的初始突释比乳化静电喷雾微球明显更轻微。同轴组的载药效率明显更高（p<0.05）。这表明，乳化和同轴静电喷雾都可以制备具有持续释放行为的载药微球，但前者更适合药物传递。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/17975616005a/MNC-30-490-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/f617515e75ac/MNC-30-490-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/feae88f44151/MNC-30-490-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/edf2269a9be1/MNC-30-490-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/1eb1e1b2fa3d/MNC-30-490-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/17975616005a/MNC-30-490-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/f617515e75ac/MNC-30-490-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/feae88f44151/MNC-30-490-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/edf2269a9be1/MNC-30-490-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/1eb1e1b2fa3d/MNC-30-490-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fff/3709885/17975616005a/MNC-30-490-g005.jpg

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本文引用的文献

[1]
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J Control Release. 2011-5-26

[2]
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