Department of Inorganic Chemistry, University of Madras, Maraimalai Campus, Chennai 600025, India.
J Biomed Nanotechnol. 2011 Feb;7(1):150-1. doi: 10.1166/jbn.2011.1244.
Tuberculosis (TB) is the leading cause of infectious diseases affecting the 2 billion people worldwide. To improve the current method of treatment a synthetic polymeric anti-TB nanodrug delivery system was attempted. A series of PLGA polymers with different molar feed ratios i.e., 90/10, 75/25, 50/50 were synthesized by direct melt polycondensation method. The PLGA nanoparticles and the drug (Rifampicin (RIF)) encapsulation were prepared by double emulsion-solvent evaporation technique. The in vitro release profile of the RIF loaded PLGA NPs showed an initial burst followed by sustained release. The nanoparticles were remarkably advantageous in terms of high drug encapsulation efficiency, low polymer consumption and better sustained release profile.
结核病（TB）是全球 20 亿人感染的主要传染病病因。为了改善当前的治疗方法，尝试了一种合成聚合物抗结核纳米药物递送系统。通过直接熔融缩聚法合成了一系列不同摩尔进料比的 PLGA 聚合物，即 90/10、75/25、50/50。通过双乳液-溶剂蒸发技术制备了 PLGA 纳米颗粒和药物（利福平（RIF））包封物。负载 RIF 的 PLGA NPs 的体外释放曲线显示出初始突释，随后是持续释放。在高药物包封效率、低聚合物消耗和更好的持续释放方面，纳米颗粒具有显著优势。
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