Eye Center of Diathlasis, Thessaloniki, Greece.
J Refract Surg. 2012 Nov;28(11):793-9. doi: 10.3928/1081597X-20121011-08.
To evaluate the outcomes of corneal collagen cross-linking (CXL) in pediatric patients with bilateral progressive keratoconus.
This retrospective case series included four pediatric patients (eight eyes) with progressive keratoconus aged 14.0±2.2 years (range: 11 to 16 years). All eyes underwent CXL in accordance with the standard Dresden protocol. Pre- and 1-, 12-, 24-, and 36-month postoperative examinations included corneal thickness at the thinnest point (using a topographic system), corneal topographic evaluation (flat and steep meridian keratometry [K1 and K2]), refraction, and visual acuity.
All patients completed 36-month follow-up. No intra- or postoperative complications were observed. Stabilization of K1 and K2 was demonstrated in all cases throughout follow-up (from the first postoperative interval), while visual acuity improved in six eyes and remained stable in the remaining two eyes. Manifest refraction remained stable, and corneal thickness decreased at the first postoperative month with gradual return to preoperative values during follow-up.
Preliminary data of four pediatric patients with moderate keratoconus show feasibility of treatment by CXL in these select patients with no intra- or postoperative complications over 3-year follow-up.
评估角膜胶原交联（CXL）治疗双侧进行性圆锥角膜儿童患者的疗效。
本回顾性病例系列研究纳入了 4 名（8 只眼）年龄为 14.0±2.2 岁（范围：11 至 16 岁）的进行性圆锥角膜儿童患者。所有患者均按照标准的德累斯顿方案行 CXL。术前和术后 1、12、24 和 36 个月的检查包括角膜最薄点的角膜厚度（使用地形图系统）、角膜地形图评估（平坦子午线和陡峭子午线角膜曲率[K1 和 K2]）、屈光度和视力。
所有患者均完成了 36 个月的随访。无术中或术后并发症发生。所有患者在整个随访期间（从术后第一个间隔开始）均显示出 K1 和 K2 的稳定，而 6 只眼的视力提高，2 只眼的视力保持稳定。显知觉屈光度保持稳定，角膜厚度在术后第一个月下降，随后在随访期间逐渐恢复到术前水平。
4 名中度圆锥角膜儿童患者的初步数据表明，在 3 年的随访中，CXL 治疗这些特定患者是可行的，且无术中或术后并发症。
