Department of Clinical Psychology, University of Bergen, Norway.
J Affect Disord. 2013 Aug 15;150(1):152-5. doi: 10.1016/j.jad.2012.12.017. Epub 2013 Jan 22.
Patients with panic disorder (PD) are known to report impaired sleep quality and symptoms of insomnia. PD is an anxiety disorder characterised by deficient physiological regulation as measured by heart rate variability (HRV), and reduced HRV, PD and insomnia have all been related to impaired inhibitory ability. The present study aimed to investigate the interrelationships between subjectively reported sleep impairment, cognitive inhibition and vagally mediated HRV in a sample characterised by variability on measures of all these constructs.
Thirty-six patients with PD with or without agoraphobia were included. Cognitive inhibition was assessed with the Color-Word Interference Test from the Delis-Kaplan Executive Function System (D-KEFS), HRV was measured using high frequency (HF) power (ms(2)), and subjectively reported sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI).
Cognitive inhibition was related to both Sleep latency and Sleep disturbances, whereas HRV was only related to Sleep disturbances. These relationships were significant also after controlling for depression.
Correlational design.
Cognitive inhibition is related to key insomnia symptoms: sleep initiation and sleep maintenance. The data supports the psychobiological inhibition model of insomnia, and extends previous findings. Possible clinical implications of these findings are discussed.
患有惊恐障碍（PD）的患者被认为存在睡眠质量受损和失眠症状。PD 是一种焦虑障碍，其特征是心率变异性（HRV）的生理调节不足，而 HRV 降低、PD 和失眠都与抑制能力受损有关。本研究旨在调查在一组具有所有这些结构测量变异性的样本中，主观报告的睡眠障碍、认知抑制和迷走神经介导的 HRV 之间的相互关系。
纳入了 36 名患有或不伴有广场恐怖症的 PD 患者。认知抑制采用德利斯-卡普兰执行功能系统（D-KEFS）的颜色-单词干扰测试进行评估，HRV 使用高频（HF）功率（ms²）进行测量，主观报告的睡眠质量采用匹兹堡睡眠质量指数（PSQI）进行测量。
认知抑制与睡眠潜伏期和睡眠障碍有关，而 HRV 仅与睡眠障碍有关。这些关系在控制抑郁后仍然显著。
相关设计。
认知抑制与关键的失眠症状有关：入睡和睡眠维持。该数据支持失眠的心理生物学抑制模型，并扩展了以前的发现。讨论了这些发现的可能临床意义。
