Department of Surgery, King Hussein Cancer Center, P.O.Box 1269, Al-Jubeiha, Amman 11941, Jordan.
Eur J Surg Oncol. 2013 Apr;39(4):404-7. doi: 10.1016/j.ejso.2013.01.001. Epub 2013 Jan 21.
The aim of this study was to examine the type and frequency of perianal conditions in a contemporary series of febrile neutropenic patients and to examine the risk factors, management options and outcome of septic perianal conditions.
Medical records of all adult febrile neutropenic patients (933 patients) who were admitted during the period from January, 2009 to December 2011 were retrospectively review. All patients with perianal complaints or conditions were included. The clinical features, management and outcome of septic conditions were recorded.
Of all the reviewed charts, 101 (10.8%) had perianal complaints or conditions. Most of them were non septic (74.3%), like piles and fissures, and were treated conservatively. In 26 patients the diagnosis was a septic condition: abscess (12 patients), fistula (4), inflammation (9) and necrotizing fasciitis (1). Septic conditions were more commonly found in males younger than 40 years. Surgery was done in 13 patients to drain a collection and in 2 patients to debride necrotic tissue. Most patients who had no collection had conservative management. There was 1 fatality only (3.8%) in those 26 patients.
Most of the perianal conditions in febrile neutropenic patients are non septic and are managed conservatively. Septic perianal conditions are not associated with a poor prognosis as in the past. Surgical drainage should be reserved to conditions where there is a collection; otherwise patients should be managed conservatively but with close monitoring.
本研究旨在检查当代发热性中性粒细胞减少症患者中肛周疾病的类型和频率,并检查脓毒性肛周疾病的危险因素、治疗选择和结局。
回顾性分析 2009 年 1 月至 2011 年 12 月期间收治的所有成人发热性中性粒细胞减少症患者(933 例)的病历。所有有肛周不适或疾病的患者均被纳入研究。记录脓毒症患者的临床特征、处理和结局。
在所有被审查的病历中,有 101 例(10.8%)存在肛周不适或疾病。其中大部分是非脓毒性的(74.3%),如痔疮和肛裂,均采用保守治疗。26 例患者被诊断为脓毒症:脓肿(12 例)、瘘管(4 例)、炎症(9 例)和坏死性筋膜炎(1 例)。脓毒症在 40 岁以下的男性中更为常见。13 例患者进行了引流术,2 例患者进行了清创术。大多数无脓肿的患者采用保守治疗。在这 26 例患者中,仅有 1 例死亡(3.8%)。
发热性中性粒细胞减少症患者的大多数肛周疾病是非脓毒性的,采用保守治疗。与过去相比,脓毒性肛周疾病的预后并不差。只有在有脓肿的情况下才应进行外科引流;否则,应采用保守治疗,但要密切监测。