Department of Neurology, Washington University in Saint Louis, Saint Louis, MO, USA.
Sleep Med. 2013 Aug;14(8):768-74. doi: 10.1016/j.sleep.2012.09.026. Epub 2013 Jan 21.
Rapid eye movement (REM) sleep behavior disorder (RBD) occurring prior to age 50 is termed early-onset RBD. Early-onset RBD comprises a substantial minority of cases, and demonstrates the differences in demographics, comorbidities, and clinical considerations from previously described typical RBD with onset >50years. The world literature on RBD is reviewed with specific focus on features that distinguish early-onset RBD, including more gender parity, increased proportion of idiopathic cases, increased proportion of cases associated with narcolepsy, parasomnia overlap disorder, antidepressants, and possibly autoimmune disorders, and clinical presentation.
快速眼动（REM）睡眠行为障碍（RBD）发生在 50 岁之前称为早发性 RBD。早发性 RBD 占少数，与之前描述的 50 岁以后发病的典型 RBD 在人口统计学、合并症和临床注意事项方面存在差异。本文对 RBD 的世界文献进行了回顾，重点介绍了区分早发性 RBD 的特征，包括更多的性别平等、特发性病例比例增加、与发作性睡病、睡眠-觉醒节律障碍重叠、抗抑郁药相关的病例比例增加、可能与自身免疫性疾病有关的病例比例增加，以及临床表现。
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