猝倒型发作性睡病伴夜间强迫行为：一项病例对照研究。
Narcolepsy with cataplexy associated with nocturnal compulsive behaviors: a case-control study.
机构信息
Department of Neurological Sciences University of Bologna, Bologna, Italy.
出版信息
Sleep. 2011 Oct 1;34(10):1365-71. doi: 10.5665/SLEEP.1280.
STUDY OBJECTIVES
To assess the prevalence of sleep related-eating disorder (SRED) and nocturnal smoking (NS) in patients with narcolepsy with cataplexy (NC).
DESIGN
Case-control study.
SETTING
University hospital.
PATIENTS OR PARTICIPANTS
65 consecutive adult NC patients (33 men; mean age 43.9 ± 19.2 years) and 65 age-, sex-, and geographical origin-matched controls.
INTERVENTIONS
Validated questionnaires were used to investigate SRED, NS, restless legs syndrome (RLS), and psychopathological traits (using Eating Disorder Inventory-2 [EDI-2]; Maudsley Obsessive-Compulsive Inventory [MOCI]; and Beck Depression Inventory [BDI]).
MEASUREMENTS AND RESULTS
NC patients showed a higher prevalence of SRED (32% vs 3%, P=0.00001), NS (21% vs 0%, P=0.00006), and RLS (18% vs 5%, P=0.013) than controls. Moreover, NC patients presented more frequently with an eating-related pathological profile on the EDI-2 (80% vs 46%, P=0.00006) and had a higher prevalence of depressed mood on the BDI (41% vs 18%, P=0.004). In comparison to patients without SRED, NC patients with SRED were more frequently women (71% vs 39%, P=0.013), had higher "bulimic" (29% vs 2%, P=0.004) and "social insecurity" (48% vs 18%, P=0.013) traits on the EDI-2, had higher obsessive-compulsiveness on the MOCI (29% vs 4%, P = 0.009), and were more depressed on the BDI (67% vs 29%, P=0.005). NC patients with NS showed more frequent pathological profiles on the EDI-2 (100% vs 75%, P=0.035), including the "bulimic" (29% vs 6%, P=0.015), "perfectionism" (43% vs 14%, P=0.016), and "social insecurity" (50% vs 22, P=0.035) profiles.
CONCLUSION
Our study shows a strong association of the compulsive nocturnal behaviors SRED and NS with adult NC.
研究目的
评估猝倒型发作的嗜睡症（narcolepsy with cataplexy，NC）患者中睡眠相关进食障碍（sleep related-eating disorder，SRED）和夜间吸烟（nocturnal smoking，NS）的患病率。
设计
病例对照研究。
地点
大学医院。
患者或参与者
65 例连续成年 NC 患者（33 名男性；平均年龄 43.9±19.2 岁）和 65 名年龄、性别和原籍地匹配的对照组。
干预措施
使用经过验证的问卷调查 SRED、NS、不宁腿综合征（restless legs syndrome，RLS）和精神病理学特征（使用饮食障碍问卷-2 [Eating Disorder Inventory-2，EDI-2]；莫德斯利强迫症量表 [Maudsley Obsessive-Compulsive Inventory，MOCI]；贝克抑郁量表 [Beck Depression Inventory，BDI]）。
测量和结果
与对照组相比，NC 患者 SRED（32% vs 3%，P=0.00001）、NS（21% vs 0%，P=0.00006）和 RLS（18% vs 5%，P=0.013）的患病率更高。此外，NC 患者在 EDI-2 上表现出更频繁的与进食相关的病理性特征（80% vs 46%，P=0.00006），并且在 BDI 上更常出现抑郁情绪（41% vs 18%，P=0.004）。与无 SRED 的患者相比，NC 患者中 SRED 患者更多为女性（71% vs 39%，P=0.013），具有更高的“贪食”（29% vs 2%，P=0.004）和“社交不安”（48% vs 18%，P=0.013）特征在 EDI-2 上，MOCI 上的强迫性更强（29% vs 4%，P=0.009），BDI 上的抑郁程度更高（67% vs 29%，P=0.005）。NS 的 NC 患者在 EDI-2 上表现出更频繁的病理性特征（100% vs 75%，P=0.035），包括“贪食”（29% vs 6%，P=0.015）、“完美主义”（43% vs 14%，P=0.016）和“社交不安”（50% vs 22%，P=0.035）特征。
结论
我们的研究表明，强迫性夜间行为 SRED 和 NS 与成年 NC 密切相关。
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