Kaĭnova G M, Markovska D, Staneva D, Kagan V E
Biull Eksp Biol Med. 1990 Jan;109(1):35-7.
Looking for an appropriate model of accelerated aging in vivo we investigated the content of endogenous products of lipid peroxidation (LP) in the rat brain after single or 4 day-lasting intramuscular injection of complex-bind iron (ferum Hausman, 50 mg/kg body weight) like promoter of LP. We found that the single administration of this iron complex fails to induce endogenous LP; after 4 day-application of iron we observed significant increase in content of primary (lipid peroxides) and final (fluorescent) products of LP. Iron-promoted activation of endogenous LP could be abolished by animal pretreatment with the natural antioxidant alpha-tocopherol. The calcium antagonist nifedipine didn't affect the content of endogenous LP products neither alone nor in combination with alpha-tocopherol.
为寻找合适的体内加速衰老模型，我们研究了单次或连续4天肌肉注射复合结合铁（豪斯曼铁，50mg/kg体重）（作为脂质过氧化（LP）的促进剂）后大鼠脑内脂质过氧化内源性产物的含量。我们发现，单次给予这种铁复合物未能诱导内源性LP；在应用铁4天后，我们观察到LP的初级（脂质过氧化物）和最终（荧光）产物含量显著增加。用天然抗氧化剂α-生育酚对动物进行预处理可消除铁促进的内源性LP激活。钙拮抗剂硝苯地平单独使用或与α-生育酚联合使用均不影响内源性LP产物的含量。
