Golikov P P, Davydov B V, Matveev S B
Vopr Med Khim. 1987 Jan-Feb;33(1):47-50.
Effect of various stress factors (immobilization, catecholamines and glucocorticoids) on lipid peroxidation (LP) and mobilization of alpha-tocopherol in rat blood plasma were studied. Immobilization stress caused an activation of LP in blood plasma, while content of tocopherol was increased in intact animals; in adrenalectomy activation of LP and mobilization of tocopherol were not observed. In intact rats adrenaline and hydrocortisone increased similarly the content of tocopherol in blood plasma, stimulated accumulation of diene conjugates (DC); an increase in the content of Shiff bases was found only after hydrocortisone administration; simultaneous administration of both these drugs led to an increase in DC content as well as the additive effect on tocopherol mobilization was found. In adrenalectomized rats the content of DC and tocopherol were distinctly increased and a decrease in the content of Shiff bases was found after adrenaline administration; hydrocortisone did not affect the content of both DC and Shiff bases, the level of tocopherol was increased only slightly; under conditions of simultaneous administration of these drugs hydrocortisone prevented accumulation of DC in blood plasma, caused by adrenaline; the additive effect on tocopherol mobilization was not observed. The data obtained suggest that glucocorticoids realized their effect on LP via catecholamines and the decrease in the content of Shiff bases, found after adrenaline administration, occurred due to tocopherol mobilization.
研究了各种应激因素（固定、儿茶酚胺和糖皮质激素）对大鼠血浆中脂质过氧化（LP）和α-生育酚动员的影响。固定应激导致血浆中LP激活，而完整动物体内生育酚含量增加；肾上腺切除术后未观察到LP激活和生育酚动员。在完整大鼠中，肾上腺素和氢化可的松同样增加了血浆中生育酚的含量，刺激了二烯共轭物（DC）的积累；仅在给予氢化可的松后才发现席夫碱含量增加；同时给予这两种药物导致DC含量增加，并且发现对生育酚动员有相加作用。在肾上腺切除的大鼠中，给予肾上腺素后DC和生育酚含量明显增加，席夫碱含量降低；氢化可的松对DC和席夫碱的含量均无影响，生育酚水平仅略有升高；在同时给予这些药物的情况下，氢化可的松可防止肾上腺素引起的血浆中DC积累；未观察到对生育酚动员的相加作用。所获得的数据表明，糖皮质激素通过儿茶酚胺实现其对LP的作用，而给予肾上腺素后发现席夫碱含量降低是由于生育酚动员所致。
