Institute for Genetics, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str. 47A, 50674 Cologne, Germany.
Mitochondrion. 2013 Mar;13(2):134-42. doi: 10.1016/j.mito.2013.01.006. Epub 2013 Jan 22.
Cell function relies on the constant supply of ATP and it is crucial that mitochondrial ATP production adapts to environmental and cellular challenges to maintain cellular function. Key molecules in sensing cellular stress situations seem to be the PGC-family of transcriptional co-activators, which are key regulators of mitochondrial biogenesis. Recent work has identified several stress-regulated pathways that affect mitochondrial biogenesis through modulation of the activity of PGC-1α. This review focuses on caloric restriction, hypoxia as well as the role of reactive oxygen species in regulating mitochondrial biogenesis and how this process is linked to other cellular stress responses.
细胞功能依赖于 ATP 的持续供应，线粒体 ATP 生成适应环境和细胞挑战以维持细胞功能至关重要。似乎是感知细胞应激情况的关键分子是 PGC- 家族转录共激活因子，它们是线粒体生物发生的关键调节剂。最近的工作已经确定了几种应激调节途径，这些途径通过调节 PGC-1α 的活性来影响线粒体生物发生。本综述重点介绍了热量限制、缺氧以及活性氧在调节线粒体生物发生中的作用，以及这一过程如何与其他细胞应激反应相关联。
