Hermanek P
Fortschr Med. 1978 Jan 19;96(3):108-10.
In the large intestine, the pathologist has to differentiate between multiple polyps and polyposis (more than 100 polyps), further between adenomatosis (coli) and non-neoplastic (tumorlike) polyposis. Without prophylactic colectomy, in about 80% of adenomatosis patients an evolution of cancer is observed. Patients with extensive or total ulcerative colitis and a long history have an increased risk for developing carcinoma. Precancerous dysplasia can be demonstrated in rectoscopic and/or colonoscopic biopsies. Cancers complicating adenomatosis or ulcerative colitis account for only a very small proportion of large bowel carcinoma. The "adenoma-cancer sequence" is of greater importance. Colorectal polyps should be removed endoscopically whenever possible. Most gastric polyps are non-neoplastic and have no carcinomatous potential. The true adenoma and the so-called borderline lesion only can be considered as precursor of the gastric carcinoma.
在大肠，病理学家必须区分多发性息肉和息肉病（超过100个息肉），还要进一步区分腺瘤病（结肠）和非肿瘤性（肿瘤样）息肉病。若不进行预防性结肠切除术，约80%的腺瘤病患者会发生癌症进展。患有广泛性或全溃疡性结肠炎且病程较长的患者发生癌变的风险增加。癌前发育异常可在直肠镜和/或结肠镜活检中得到证实。腺瘤病或溃疡性结肠炎并发的癌症仅占大肠癌的极小比例。“腺瘤-癌序列”更为重要。只要有可能，大肠息肉都应通过内镜切除。大多数胃息肉是非肿瘤性的，没有癌变潜能。真正的腺瘤和所谓的临界病变才被视为胃癌的前驱病变。
