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[抗肿瘤药物损伤的骨髓细胞对正常脾脏效应细胞细胞毒作用的敏感性]

[Sensitivity of bone marrow cells damaged by antitumor drugs to cytotoxic action of effectors of a normal spleen].

作者信息

Klimova M Iu, Bogdashin I V, Novitskiĭ V V, Gol'dberg E D

出版信息

Biull Eksp Biol Med. 1990 Jan;109(1):60-2.

PMID:2334801
Abstract

Different cytogenetic effects in bone marrow cells induced by antitumor drugs with different mechanisms of action was studied. The treatment of adriablastine causes the appearance of chromatid deletion, vinblastine-polyploid cells, cyclophosphamide-chromosomal and chromatid aberration in mice. It was shown that bone marrow cells with cytogenetic damage have altered susceptibility to normal spleen cells-effectors cytotoxic action.

摘要

研究了具有不同作用机制的抗肿瘤药物对骨髓细胞的不同细胞遗传学效应。阿霉素处理导致小鼠出现染色单体缺失，长春花碱处理导致多倍体细胞出现，环磷酰胺处理导致染色体和染色单体畸变。结果表明，具有细胞遗传学损伤的骨髓细胞对正常脾细胞效应细胞的细胞毒性作用的敏感性发生了改变。

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