Romanucci M, Berardi I, Ciccarelli A, Bongiovanni L, Malatesta D, Oevermann A, Della Salda L
Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, Piazza A Moro 45, 64100 Teramo, University of Teramo, Piazza A Moro 45, 64100 Teramo, Italy.
J Comp Pathol. 2013 Aug-Oct;149(2-3):216-20. doi: 10.1016/j.jcpa.2012.11.240. Epub 2013 Jan 22.
Abnormal expression of heat shock proteins (HSPs) has been observed in many human neoplasms and such expression has prognostic, predictive and therapeutic implications. The aim of this study was to evaluate immunohistochemically the expression of HSP 27, HSP 32 and HSP 90 in normal canine peripheral nerves and in four benign and 15 malignant canine peripheral nerve sheath tumours (PNSTs). In normal nerve, all of the HSPs were detected in axons, epineurial fibroblasts and scattered Schwann cell bodies. Cytoplasmic expression of HSP 27 was more widespread and intense in benign PNSTs compared with malignant PNSTs (P <0.05). Widespread and intense nuclear expression of HSP 32 was also associated with benign tumours (P <0.01), while high HSP 90 immunoreactivity was detected in all tumours, suggesting that HSP 90 might represent a new therapeutic target.
