Department of Mechanical and Mechatronic Engineering, National Taiwan Ocean University, Keelung 20224, Taiwan.
Lab Chip. 2013 Mar 21;13(6):1114-20. doi: 10.1039/c2lc41050h.
Using a cell culture chip with a deformable substrate driven by a hydraulic force, we investigated the motility of cancer cells affected by myofibroblasts undergoing cyclic tensile strain (CTS). CTS reduced both the expression of α-smooth muscle actin in the myofibroblast and the ability of the myofibroblast to accelerate cancer cell migration. However, with the treatment of a pro-inflammatory factor interleukin-1β on the myofibroblasts, the effects of CTS on the myofibroblast were diminished. This result suggests an antagonism between mechanical and chemical stimulations on mediating cancer metastasis by the stromal myofibroblast.
利用由液压驱动的可变形基底的细胞培养芯片，我们研究了受周期性张力应变（CTS）影响的肌成纤维细胞的运动性。CTS 降低了肌成纤维细胞中α-平滑肌肌动蛋白的表达，以及肌成纤维细胞加速癌细胞迁移的能力。然而，在用促炎因子白细胞介素-1β处理肌成纤维细胞后，CTS 对肌成纤维细胞的作用减弱了。这一结果表明，在由基质肌成纤维细胞介导的癌症转移中，机械刺激和化学刺激之间存在拮抗作用。
