Department of Cell Biology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Department of Pathology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Semin Cell Dev Biol. 2019 Sep;93:36-45. doi: 10.1016/j.semcdb.2018.07.014. Epub 2018 Sep 5.
Tumor invasion along structural interphases of surrounding tumor-free tissue represents a key process during tumor progression. Much attention has been devoted to mechanisms of tumor cell migration within extracellular matrix (ECM)-rich connective tissue, however a comprehensive understanding of tumor invasion into tissue of higher structural complexity, such as muscle tissue, is lacking. Muscle invasion in cancer patients is often associated with destructive growth and worsened prognosis. Here, we review biochemical, geometrical and mechanical cues of smooth and skeletal muscle tissues and their relevance for guided invasion of cancer cells. As integrating concept, muscle-organizing ECM-rich surfaces of the epi-, peri- and endomysium provide cleft-like confined spaces along interfaces between dynamic muscle cells, which provide molecular and physical cues that guide migrating cancer cells, forming a possible contribution to cancer progression.
肿瘤沿着周围无肿瘤组织的结构界面侵袭是肿瘤进展过程中的一个关键过程。人们已经关注了肿瘤细胞在富含细胞外基质（ECM）的结缔组织中迁移的机制，然而，对于肿瘤侵入结构更为复杂的组织（如肌肉组织）的全面了解还很缺乏。癌症患者的肌肉侵袭常常与破坏性生长和预后恶化有关。在这里，我们回顾了平滑肌和骨骼肌组织的生化、几何和力学线索及其对癌细胞定向侵袭的相关性。作为一个整合的概念，肌组织的 ECM 丰富的表面，包括上皮、周和内膜组织，沿着动态肌细胞之间的界面提供了裂隙状的受限空间，为迁移的癌细胞提供了分子和物理线索，形成了对癌症进展的可能贡献。
