Taş Ahmet, Cakir Gundogan Fatih, Akgun Hakan, Erdem Uzeyir, Sobaci Gungor
Department of Ophthalmology, Gulhane Military Medical Academy, 2Department of Neurology, Etimesgut Military Hospital; Ankara, Turkey.
Med Glas (Zenica). 2013 Feb;10(1):99-105.
To explore amplitude and latency-check size function in multiple sclerosis (MS) patients without optic neuritis history.
Thirty-six MS patients and 21 control subjects were included. Pattern visual evoked responses to ive check sizes (2°, 1°, 30', 15', and 7') were recorded.
P100 amplitudes were significantly reduced in 2°, 1° and 7' checks and, P100 latencies were significantly delayed in all checks in MS patients (p < 0.05). Inter-ocular amplitude/ latency differences were significantly higher in MS patients than control group (p < 0.05). The P100 amplitudes for 2° check was somewhat higher than amplitudes for 1° check in MS and control groups. However, MS patients had latter amplitude-check size function curve in large checks. In small checks, the slope of the amplitude-check size curves were similar for MS and control groups. The flattening of amplitude-check size function curve in large checks increased in MS patients with reduced P100 amplitudes. The P100 amplitudes for 2° check was lower than P100 amplitudes for 1° check in MS patients with reduced P100 amplitudes in contrast to normal subjects and MS patients with normal P100 amplitudes. Both groups had almost parallel P100 latency-check size curves in all checks. With respect to 95% confidence limit in control subjects in each check sizes, the number of eyes with delayed latency and reduced amplitude in MS patients were higher in large checks.
This study showed that P100 amplitudes are reduced in MS patients without optic neuritis history, and responses to large checks are affected more than small checks.
探讨无视神经炎病史的多发性硬化症（MS）患者的振幅和潜伏期-视标大小函数。
纳入36例MS患者和21例对照受试者。记录对五种视标大小（2°、1°、30′、15′和7′）的图形视觉诱发电位。
MS患者中，2°、1°和7′视标检查时P100振幅显著降低，所有视标检查时P100潜伏期均显著延迟（p<0.05）。MS患者双眼间的振幅/潜伏期差异显著高于对照组（p<0.05）。MS组和对照组中，2°视标检查的P100振幅略高于1°视标检查的振幅。然而，MS患者在大视标检查时的振幅-视标大小函数曲线较低。在小视标检查中，MS组和对照组的振幅-视标大小曲线斜率相似。大视标检查时，MS患者中P100振幅降低者的振幅-视标大小函数曲线变平情况增加。与正常受试者和P100振幅正常的MS患者相比，P100振幅降低的MS患者中，2°视标检查的P100振幅低于1°视标检查的P100振幅。两组在所有视标检查中P100潜伏期-视标大小曲线几乎平行。在各视标大小的对照组95%置信限范围内，MS患者中大视标检查时潜伏期延迟和振幅降低的眼数更多。
本研究表明，无视神经炎病史的MS患者P100振幅降低，对大视标检查的反应比对小视标检查的影响更大。
