Department of Neurology and Clinical Neurophysiology, Royal North Shore Hospital, Australia; The University of Sydney, Sydney, NSW, Australia.
Department of Neurology and Clinical Neurophysiology, Royal North Shore Hospital, Australia.
J Clin Neurosci. 2020 May;75:181-187. doi: 10.1016/j.jocn.2020.01.045. Epub 2020 Apr 1.
Pattern reversal visual evoked potentials have been used to study optic neuritis. Although smaller check size in the central fields are more sensitive, larger check sizes can be advantageous for patient fixation and in poor vision. We compared sectorial central and peripheral hemisurround stimulus with commonly used full- and half- field stimulus using large check sizes (65') in the context of optic neuritis and multiple sclerosis. Of 19 female and 16 male control subjects studied, females had shorter P100 latencies and larger amplitudes than males. In 9 of the 18 patients with VEP abnormalities, the central field abnormalities were greater than those recorded with the full field response. The results confirm for the first time that central field stimulation using large checks can show a greater extent of abnormality than can be appreciated with large check full field stimulation alone, and could be commonly employed to improve yield in the investigation of optic neuritis. The data suggest that it is necessary to collect separate gender-specific laboratory normal values using this check size.
视觉诱发电位已被用于研究视神经炎。虽然中央视野的小检查点更敏感，但大检查点在患者固视和视力不佳时更有优势。我们比较了扇形中央和周边半视野刺激与常用的全视野和半视野刺激，在视神经炎和多发性硬化的背景下使用大检查点（65'）。在研究的 19 名女性和 16 名男性对照受试者中，女性的 P100 潜伏期比男性短，振幅比男性大。在 18 名 VEP 异常患者中，有 9 名患者的中央视野异常大于全视野反应记录的异常。结果首次证实，使用大检查点的中央视野刺激可以显示比单独使用大检查点全视野刺激更大程度的异常，并且可以普遍用于提高视神经炎的检查效果。数据表明，有必要使用这种检查大小收集单独的、基于性别的实验室正常值。
