Department of Urology, Yamamoto Kumiai General Hospital, Noshiro, Japan.
Histol Histopathol. 2013 Mar;28(3):321-6. doi: 10.14670/HH-28.321.
Neoplasms of the epididymis are uncommon, and malignant tumors are extremely rare. We report a case of clear cell papillary cystadenocarcinoma of the epididymis presenting with a long history of painless scrotal mass on the left side. Immunohistochemical markers for clear cell renal cell carcinoma (RCC) were examined to distinguish between clear cell papillary cystadenocarcinoma of the epididymis and metastatic clear cell renal cell carcinoma. The present case was positive for cytokeratin-7, PAX2, vinculin, vimentin and carbonic anhydrase IX. Expression of CD10 was focally observed. In contrast, no immunoreactivities for α-methylacyl-CoA racemase, RCC marker, glutathione S-transferase α or C-KIT were detected. The immunophenotypic profile of clear cell papillary cystadenocarcinoma of the epididymis closely resembles that of clear cell papillary RCC, although the immunohistochemical markers tested in this study are useful to make a differential diagnosis between clear cell papillary cystadenocarcinoma of the epididymis and metastatic clear cell RCC.
附睾肿瘤并不常见，恶性肿瘤则更为罕见。我们报告一例左侧无痛性阴囊肿块病史较长的附睾透明细胞乳头状囊腺癌。为了鉴别附睾透明细胞乳头状囊腺癌和转移性透明细胞肾细胞癌，我们检测了透明细胞肾细胞癌的免疫组化标志物。本病例的细胞角蛋白 7、PAX2、波形蛋白和碳酸酐酶 IX 阳性，CD10 呈局灶性阳性。相反，α-甲基酰基辅酶 A 消旋酶、肾细胞癌标志物、谷胱甘肽 S-转移酶 α 或 C-KIT 均无免疫反应性。附睾透明细胞乳头状囊腺癌的免疫表型与透明细胞乳头状肾细胞癌非常相似，尽管本研究中检测的免疫组化标志物有助于鉴别诊断附睾透明细胞乳头状囊腺癌和转移性透明细胞肾细胞癌。
