Hayashi Minoru, Shimizu Yuki, Sato Masahide, Yokoyama Toshiya, Yosimoto Shinya
From the Department of Plastic and Reconstructive Surgery, School of Medicine, Showa University, Tokyo, Japan.
Ann Plast Surg. 2014 Jul;73(1):98-101. doi: 10.1097/SAP.0b013e31826eabe3.
We examined the changes in blood flow in the femoral artery caused by botulinum toxin A in rats. Blood flow was measured using laser Doppler flowmetry. We used male Sprague-Dawley-derived rats weighing between 350 and 400 g. The study was performed on 6 groups; each of them consisted of 30 rats (control and botulinum toxin A 0.5, 1, 2, 4, and 8 units). The laser Doppler flowmetry revealed that blood flow in the femoral artery increased by the third day in the groups injected with 1 or more units of botulinum toxin A. In the groups injected with 8 units of botulinum toxin A, we recognized an increase of blood flow from the second day. Our results suggest that botulinum toxin A is concerned in improving blood flow.
我们研究了肉毒杆菌毒素A对大鼠股动脉血流的影响。采用激光多普勒血流仪测量血流。我们使用体重在350至400克之间的雄性斯普拉格-道利大鼠。该研究分为6组进行；每组由30只大鼠组成（对照组以及注射0.5、1、2、4和8单位肉毒杆菌毒素A的组）。激光多普勒血流仪显示，在注射1个或更多单位肉毒杆菌毒素A的组中，股动脉血流在第三天增加。在注射8单位肉毒杆菌毒素A的组中，我们从第二天就观察到血流增加。我们的结果表明，肉毒杆菌毒素A与改善血流有关。
