Jedynak Monika, Siemiątkowski Andrzej, Rygasiewicz Karolina
Department of Anaesthesiology and Intensive Therapy, Medical University in Białystok, 15–276 Białystok, Poland.
Anaesthesiol Intensive Ther. 2012 Oct-Dec;44(4):221-5.
Bacterial infections and sepsis remain major causes of morbidity and mortality in intensive care units. The normal host response to infection is a complex process that serves to localise and control the invasion of microbes and to repair injured tissue. Local inflammatory processes are regulated through the production of cytokines by macrophages. In some cases, mediator release exceeds the boundaries of the local environment and results in the development of sepsis. It is well known that the innate immune system plays a crucial role in preventing microbial invasion. The human innate immune system consists of genetically programmed defence mechanisms that are directed against molecular components found only in microorganisms. Understanding the complexity of early response to infection with respect to innate immune response is required for the future development of drugs that will effectively control infectious diseases.
细菌感染和脓毒症仍然是重症监护病房发病和死亡的主要原因。正常宿主对感染的反应是一个复杂的过程，其作用是定位和控制微生物的入侵，并修复受损组织。局部炎症过程通过巨噬细胞产生细胞因子来调节。在某些情况下，介质释放超过局部环境的界限，导致脓毒症的发生。众所周知，先天免疫系统在预防微生物入侵中起着关键作用。人类先天免疫系统由针对仅在微生物中发现的分子成分的基因编程防御机制组成。为了未来开发能有效控制传染病的药物，需要了解感染早期反应在先天免疫反应方面的复杂性。
