腹侧齿状回中的颗粒细胞对于海人酸诱导的湿狗样抖动至关重要，但对于吗啡依赖大鼠戒断诱发的湿狗样抖动则并非如此。

Granule cells in the ventral dentate gyrus are essential for kainic acid-induced wet dog shakes but not those induced by precipitated abstinence in morphine-dependent rats.

作者信息

Mitchell C L, Grimes L M, Hong J S

机构信息

Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.

出版信息

Brain Res. 1990 Mar 19;511(2):338-40. doi: 10.1016/0006-8993(90)90180-j.

DOI:10.1016/0006-8993(90)90180-j

PMID:2334852

Abstract

Wet dog shaking elicited by systemic administration of kainic acid is eliminated by bilateral destruction of ventral dentate granule cells. In contrast, wet dog shaking induced by naltrexone precipitated abstinence in morphine-dependent rats is unaffected by destruction of ventral dentate granule cells. It is concluded that at least two anatomically distinct brain regions modulate wet dog shaking behavior.

摘要

通过全身性给予海藻酸引发的湿狗样抖动可因双侧损毁腹侧齿状颗粒细胞而消除。相比之下，纳曲酮诱发吗啡依赖大鼠戒断所引起的湿狗样抖动不受腹侧齿状颗粒细胞损毁的影响。由此得出结论，至少有两个解剖学上不同的脑区调节湿狗样抖动行为。