Grimes L, Hong J, McGinty J, Mitchell C, Obie J, Tilson H
Curriculum in Toxicology, UNC-CH 27514.
NIDA Res Monogr. 1986;75:481-4.
Kainic acid (KA) caused an initial decrease and a subsequent rebound in hippocampal enkephalin (ENK) in rats exhibiting wet dog shakes (WDS) without behavioral convulsions. Antibody to methionine-enkephalin but not dynorphin A(1-8) injected into lateral ventricles attenuated KA-induced WDS, as did naloxone. Granule-cell destroying injections of colchicine into ventral but not dorsal hippocampus caused a 60% reduction of hippocampal ENK and a complete elimination of KA-induced WDS. These studies suggest that release of granule cell ENK, which is 3 times more concentrated in ventral than dorsal hippocampus, plays an important role in KA-induced WDS.
海藻酸（KA）使未出现行为性惊厥但表现出湿狗样抖动（WDS）的大鼠海马脑啡肽（ENK）先减少，随后出现反弹。向侧脑室注射甲硫氨酸脑啡肽抗体而非强啡肽A（1-8），以及注射纳洛酮，均可减轻KA诱导的WDS。向腹侧而非背侧海马注射秋水仙碱破坏颗粒细胞，导致海马ENK减少60%，并完全消除KA诱导的WDS。这些研究表明，颗粒细胞ENK的释放（腹侧海马中的浓度比背侧海马高3倍）在KA诱导的WDS中起重要作用。
Zotero 插件