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Colchicine lesions of ventral, but not dorsal, dentate granule cells attenuate wet dog shakes elicited by perforant path stimulation.

作者信息

Barnes M I, Mitchell C L

机构信息

Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.

出版信息

Brain Res. 1990 Mar 26;512(1):159-63. doi: 10.1016/0006-8993(90)91186-k.

DOI:10.1016/0006-8993(90)91186-k
PMID:2337804
Abstract

Intrahippocampal injections of colchicine selectively destroy dentate granule cells. Wet dog shaking elicited by perforant path stimulation is unaffected by bilateral destruction of dorsal dentate granule cells but virtually eliminated by bilateral destruction of ventral dentate granule cells. This implies that ventral dentate granule cells are essential for the generation of perforant path stimulation-induced wet dog shakes.

摘要

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1
Colchicine lesions of ventral, but not dorsal, dentate granule cells attenuate wet dog shakes elicited by perforant path stimulation.
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2
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Enkephalin contained in dentate granule cells is important for kainic acid-induced wet dog shakes.齿状颗粒细胞中含有的脑啡肽对 kainic 酸诱导的湿狗样抖动很重要。
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Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
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Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex.有证据表明，齿状颗粒细胞参与了由内嗅皮层点燃刺激所引发的湿狗样抖动。
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