State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Cancer Lett. 2013 May 10;332(1):94-101. doi: 10.1016/j.canlet.2013.01.023. Epub 2013 Jan 21.
In this study, we detected miR-206 expression in gastric cancer (GC) and further investigated its effects on GC cell growth in vitro and in vivo. miR-206 expression was found to be significantly decreased in 30 GC samples and GC cell lines by real time-PCR. Restoration of miR-206 reduced cell growth and colony forming ability in GC cells with G0/G1 cell cycle arrest. Further studies demonstrated that miR-206 could suppress GC cells proliferation at least partially through targeting the cyclinD2 (CCND2). Therefore, we provided evidence that miR-206 was a potential tumor suppressor and may be used as a therapeutic target for gastric cancer.
在这项研究中，我们检测了胃癌（GC）中的 miR-206 表达，并进一步研究了其对 GC 细胞在体外和体内生长的影响。实时 PCR 显示，30 例 GC 样本和 GC 细胞系中的 miR-206 表达明显降低。miR-206 的恢复降低了 GC 细胞的细胞生长和集落形成能力，导致 G0/G1 细胞周期停滞。进一步的研究表明，miR-206 至少可以通过靶向 cyclinD2（CCND2）来抑制 GC 细胞的增殖。因此，我们提供了证据表明 miR-206 是一种潜在的肿瘤抑制因子，可作为胃癌的治疗靶点。
