Berlin Ultrahigh Field Facility (B.U.F.F), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany.
J Magn Reson Imaging. 2013 Jun;37(6):1342-50. doi: 10.1002/jmri.23924. Epub 2013 Jan 24.
To establish a suitable setup for combining isometric handgrip exercise with cardiovascular magnetic resonance (CMR) imaging and to assess cardiovascular effects.
Fifty-three healthy volunteers (31 males, mean age 45 ± 17 years) underwent handgrip exercise in a 3T scanner using a prototype handgrip system and a custom-made feedback system that displayed the force. Handgrip was sustained at 30% of the maximal contraction for 6-8 minutes. Heart rate, blood pressure (BP), and double product were determined sequentially. Stroke volume was quantified in a subgroup (n = 21) at rest and stress using phase contrast acquisitions.
Heart rate increased significantly between rest and stress by 20 ± 13%, systolic / diastolic / mean BP by 15 ± 11% / 20 ± 18% / 17 ± 13%, double product by 37 ± 21%, and cardiac output by 27 ± 16% (each P < 0.001). Stroke volume did not significantly increase (3 ± 9%; P = 0.215). Higher age was associated with reduced increase of stroke volume (P = 0.022) and cardiac output (P < 0.001). Overweight subjects showed less increases in heart rate (P = 0.021) and cardiac output (P = 0.002).
The handgrip exercise during CMR with the presented set-up leads to considerable hemodynamic changes in healthy volunteers.
建立一种合适的方案，将等长握力运动与心血管磁共振（CMR）成像相结合，并评估其心血管效应。
53 名健康志愿者（31 名男性，平均年龄 45 ± 17 岁）在 3T 扫描仪中使用原型握力系统和定制的反馈系统进行握力运动，该系统显示握力的力量。握力持续 6-8 分钟，达到最大收缩力的 30%。依次测量心率、血压（BP）和双乘积。在亚组（n = 21）中使用相位对比采集在休息和应激时定量评估心搏量。
与休息时相比，应激时心率显著增加 20 ± 13%，收缩压/舒张压/平均 BP 增加 15 ± 11%/20 ± 18%/17 ± 13%，双乘积增加 37 ± 21%，心输出量增加 27 ± 16%（均 P < 0.001）。但心搏量无明显增加（3 ± 9%；P = 0.215）。年龄较大与心搏量和心输出量增加减少相关（P = 0.022 和 P < 0.001）。超重受试者的心率（P = 0.021）和心输出量（P = 0.002）增加较少。
本研究中介绍的 CMR 检查中使用的握力运动方案可引起健康志愿者的显著血流动力学变化。
