Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College Shunqing District, Nanchong, Sichuan, China.
J Magn Reson Imaging. 2013 Sep;38(3):540-7. doi: 10.1002/jmri.24007. Epub 2013 Jan 24.
To investigate whether and how spleen size measured on magnetic resonance imaging (MRI) could be used to stage liver fibrosis.
Sixteen minipigs were used to prospectively model liver fibrosis staged by biopsy. Abdominal gadolinium-enhanced MRI was performed on the 0, 5th, 9th, 16th, and 21st weekend after beginning of the modeling. Splenic maximal width (W), thickness (T), length (L), and area (S) together with spleen volume (SV) and liver volume (LV) were measured on enhanced MRI and the ratio of SV to LV (SV/LV) was calculated. Spleen multidimensional indexes 1 and 2 were obtained by W × T × L and S × L, respectively. Statistical analyses were performed to determine which parameter could best stage the fibrosis.
W, T, L, S, SV, index 1 and 2, and SV/LV tended to increase with increasing stages of fibrosis (r = 0.46-0.796, all P < 0.001), and might predict liver fibrosis stage ≥1, ≥2, ≥3, and 4 (area under receiver operating characteristic curve [AUC] = 0.697-1.0, all P < 0.05). Among the parameters, splenic index 1, SV, and SV/LV might be best for predicting stage ≥1 (AUC = 0.941), ≥2 or ≥3 (AUC = 0.875 or 0.978, respectively), and 4 (AUC = 1.0), respectively.
Spleen size measured on MRI could be used for staging liver fibrosis.
研究磁共振成像（MRI）测量的脾脏大小是否以及如何用于分期肝纤维化。
16 头小型猪前瞻性地用于通过活检建模肝纤维化分期。在建模开始后的第 0、5、9、16 和 21 周末进行腹部钆增强 MRI。在增强 MRI 上测量脾脏的最大宽度（W）、厚度（T）、长度（L）和面积（S）以及脾脏体积（SV）和肝脏体积（LV），并计算 SV/LV 的比值。通过 W×T×L 和 S×L 获得脾脏多维指数 1 和 2。进行统计分析以确定哪个参数可以最佳分期纤维化。
W、T、L、S、SV、指数 1 和 2 以及 SV/LV 随着纤维化阶段的增加而增加（r = 0.46-0.796，均 P <0.001），并且可能预测肝纤维化分期≥1、≥2、≥3 和 4（曲线下面积[AUC] = 0.697-1.0，均 P <0.05）。在这些参数中，脾指数 1、SV 和 SV/LV 可能最适合预测分期≥1（AUC = 0.941）、≥2 或≥3（AUC = 0.875 或 0.978）和 4（AUC = 1.0）。
MRI 测量的脾脏大小可用于分期肝纤维化。
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