Foschini Maria P, Leonardi Elisa, Eusebi Leonardo Henry, Farnedi Anna, Poli Tito, Tarsitano Achille, Cocchi Roberto, Marchetti Claudio, Gentile Luciano, Sesenna Enrico, Marucci Gianluca, Montebugnoli Lucio
University of Bologna at Bellaria Hospital, Bologna, Italy.
Int J Surg Pathol. 2013 Apr;21(2):133-41. doi: 10.1177/1066896912471851. Epub 2013 Jan 24.
Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early or late metastases and, moreover, in planning the proper therapeutic procedures before surgery. To this end, immunohistochemical expressions of both E-cadherin and podoplanin were evaluated on preoperative incisional biopsies of OSCC from 102 patients. The probability to have or develop metastases was very low when high E-cadherin expression was found in a preoperative sample or when a low podoplanin expression was found. Therefore, because of the strong association with LN metastases, high E-cadherin/low podoplanin immunohistochemical expression should also be assessed on preoperative incisional biopsies as a useful tool for evaluating the probability of early or late LN metastases of OSCCs.
颈部淋巴结转移是口腔鳞状细胞癌（OSCC）预后的一个重要独立不良指标。准确评估有利于转移过程的分子模式有助于预测早期或晚期转移可能性较高的OSCC病例，此外，还有助于在手术前规划适当的治疗程序。为此，对102例OSCC患者术前切取活检标本进行了E-钙黏蛋白和血小板内皮细胞黏附分子的免疫组化表达评估。当术前样本中发现E-钙黏蛋白高表达或血小板内皮细胞黏附分子低表达时，发生转移的可能性非常低。因此，由于与淋巴结转移密切相关，术前切取活检标本时也应评估E-钙黏蛋白高表达/血小板内皮细胞黏附分子低表达，作为评估OSCC早期或晚期淋巴结转移可能性的有用工具。
