Department of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical Science, 13-1 Takara-Machi, Kanazawa, 920-8641, Japan.
Diagn Pathol. 2023 Aug 3;18(1):87. doi: 10.1186/s13000-023-01371-3.
To determine the predictive indexes of late cervical lymph node metastasis in early tongue squamous cell carcinoma (TSCC). We retrospectively analyzed the cases of 25 patients with stage I/II TSCC who had undergone surgical treatment without elective neck dissection. We evaluated the relationships between clinicopathologic factors and the occurrence of late cervical lymph node metastasis. Of the 25 cases, metastasis to the cervical lymph nodes was observed in nine cases (36.0%). The clinicopathological factors associated with late cervical lymph node metastasis were the mode of invasion (MOI, p = 0.032), depth of invasion (DOI, p = 0.004), and perineural invasion (PNI, p = 0.040). A multivariate analysis revealed that only the DOI was an independent predictor of late cervical lymph node metastasis. The combination of the DOI and MOI or the PNI and MOI was significantly correlated with late cervical lymph node metastasis (p = 0.004 and p = 0.012, respectively). Our findings suggest that combinations of the MOI, DOI, and PNI could be used as an index for predicting late cervical lymph node metastasis in early TSCC.
为了确定早期舌鳞癌（TSCC）中晚期颈淋巴结转移的预测指标。我们回顾性分析了 25 例接受手术治疗且未行选择性颈清扫术的 I/II 期 TSCC 患者的病例。我们评估了临床病理因素与晚期颈淋巴结转移发生之间的关系。在 25 例患者中，9 例（36.0%）发生了颈淋巴结转移。与晚期颈淋巴结转移相关的临床病理因素为侵袭模式（MOI，p=0.032）、浸润深度（DOI，p=0.004）和神经周围侵犯（PNI，p=0.040）。多因素分析显示，仅 DOI 是晚期颈淋巴结转移的独立预测因子。DOI 与 MOI 或 PNI 与 MOI 的组合与晚期颈淋巴结转移显著相关（p=0.004 和 p=0.012）。我们的研究结果表明，MOI、DOI 和 PNI 的组合可作为预测早期 TSCC 中晚期颈淋巴结转移的指标。
