通过消除腈基的镍催化环加成合成喹诺酮。
Synthesis of quinolones by nickel-catalyzed cycloaddition via elimination of nitrile.
机构信息
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
出版信息
Org Lett. 2013 Feb 15;15(4):856-9. doi: 10.1021/ol303546p. Epub 2013 Jan 25.
PMID:23351012
Abstract
Substituted quinolones were efficiently synthesized via the nickel-catalyzed cycloaddition of o-cyanophenylbenzamide derivatives with alkynes. The reaction involves elimination of a nitrile group by cleavage of the two independent aryl-cyano and aryl-carbonyl C-C bonds of the amides.
摘要
取代的喹诺酮类化合物可通过镍催化邻氰基苯甲酰胺衍生物与炔烃的环加成反应高效合成。该反应涉及酰胺的两个独立的芳基氰基和芳基羰基 C-C 键的断裂，通过消除一个腈基团。
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