Department of Medical Biotechnology, Soonchunhyang University, Asan, Korea.
BMB Rep. 2013 Jan;46(1):17-24. doi: 10.5483/bmbrep.2013.46.1.001.
Transcutaneous immunization refers to the topical application of antigens onto the epidermis. Transcutaneous immunization targeting the Langerhans cells of the skin has received much attention due to its safe, needle-free, and noninvasive antigen delivery. The skin has important immunological functions with unique roles for antigen-presenting cells such as epidermal Langerhans cells and dermal dendritic cells. In recent years, novel vaccine delivery strategies have continually been developed; however, transcutaneous immunization has not yet been fully exploited due to the penetration barrier represented by the stratum corneum, which inhibits the transport of antigens and adjuvants. Herein we review recent achievements in transcutaneous immunization, focusing on the various strategies for the enhancement of antigen delivery and vaccination efficacy.
经皮免疫是指将抗原施用于表皮。由于经皮免疫是一种安全、无针、非侵入性的抗原传递方式，因此针对皮肤朗格汉斯细胞的经皮免疫受到了广泛关注。皮肤具有重要的免疫功能，表皮朗格汉斯细胞和真皮树突状细胞等抗原呈递细胞具有独特的作用。近年来，新的疫苗传递策略不断得到发展；然而，由于角质层构成的穿透障碍，经皮免疫尚未得到充分利用，该障碍抑制了抗原和佐剂的传递。本文综述了经皮免疫的最新研究进展，重点介绍了增强抗原传递和疫苗效力的各种策略。
