a 1 Department of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
b 2 China-US Vaccine Research Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Expert Rev Vaccines. 2015;14(11):1509-23. doi: 10.1586/14760584.2015.1081067. Epub 2015 Aug 27.
The many factors impacting the efficacy of a vaccine can be broadly divided into three categories: features of the vaccine itself, including immunogen design, vaccine type, formulation, adjuvant and dosing; individual variations among vaccine recipients and vaccine administration-related parameters. While much literature exists related to vaccines, and recently systems biology has started to dissect the impact of individual subject variation on vaccine efficacy, few studies have focused on the role of vaccine administration-related parameters on vaccine efficacy. Parenteral and mucosal vaccinations are traditional approaches for licensed vaccines; novel vaccine delivery approaches, including needless injection and adjuvant formulations, are being developed to further improve vaccine safety and efficacy. This review provides a brief summary of vaccine administration-related factors, including vaccination approach, delivery route and method of administration, to gain a better understanding of their potential impact on the safety and immunogenicity of candidate vaccines.
疫苗本身的特点，包括免疫原设计、疫苗类型、配方、佐剂和剂量；疫苗接种者个体差异和与疫苗接种相关的参数。尽管有大量相关疫苗的文献，最近系统生物学也开始剖析个体差异对疫苗效力的影响，但很少有研究关注与疫苗接种相关的参数对疫苗效力的作用。 肌肉注射和黏膜接种是传统的已许可疫苗接种方法；新型疫苗递送方法，包括无针注射和佐剂配方，正在开发中，以进一步提高疫苗的安全性和效力。本综述简要总结了与疫苗接种相关的因素，包括接种方法、递送途径和接种方式，以更好地了解它们对候选疫苗的安全性和免疫原性的潜在影响。
