Orthopaedic Research and Education Center (OREC), Attikon University Hospital, University of Athens, School of Medicine, Athens, Greece.
Injury. 2013 Jan;44 Suppl 1:S70-5. doi: 10.1016/S0020-1383(13)70016-0.
Bone loss from trauma, neoplasia, reconstructive surgery and congenital defects remains a major health problem. The long-term clinical goal is to reconstruct bony tissue in an anatomically functional three-dimensional morphology. In the extremities, bone grafts are used for the treatment of non-unions and necrotic lesions, for skeletal structural support and for the reconstruction of defects resulting from trauma, tumor excision, osteomyelitis, congenital pseudarthrosis, or radiation necrosis. In all cases their use is successful provided that the host bed has adequate vascularization. In cases of decreased blood supply, a vascularized bone graft should be applied. The intrinsic blood supply of the vascularized bone grafts leads to higher success rates and to acceleration of the repair process in the reconstruction of defects and necrotic lesions of the skeleton.
创伤、肿瘤、重建手术和先天性缺陷导致的骨质流失仍然是一个主要的健康问题。长期的临床目标是在解剖学上功能三维形态重建骨组织。在四肢，骨移植用于治疗骨不连和坏死病变，用于骨骼结构支撑和重建创伤、肿瘤切除、骨髓炎、先天性假关节或放射性骨坏死引起的缺陷。在所有情况下，只要宿主床有足够的血管化，它们的使用都是成功的。在血液供应减少的情况下，应应用带血管的骨移植物。带血管的骨移植物的固有血液供应导致更高的成功率，并加速修复过程在缺陷和骨骼坏死病变的重建。
