Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, CRC B3-4141, MSC 1684, Bethesda, MD 20892-1684, USA.
Hematol Oncol Clin North Am. 2013 Feb;27(1):89-99, viii. doi: 10.1016/j.hoc.2012.11.002. Epub 2012 Nov 22.
Chronic granulomatous disease (CGD) is a paradigm for nonlymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, vasculature, and brain. It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced HIV and before its routine use in neutropenia. It has been an attractive target for gene therapy and bone marrow transplantation for nonmalignant diseases. Therefore, CGD is worthy of attention for its historical interest and because it is a disease for which expert management is imperative.
慢性肉芽肿病（CGD）是一种非淋巴原发性免疫缺陷的范例，它指导了吞噬细胞、血管和大脑中氧代谢的阐明。在先进的 HIV 出现之前，在中性粒细胞减少症的常规使用之前，它一直处于抗菌预防的前沿。它一直是基因治疗和非恶性疾病骨髓移植的有吸引力的目标。因此，CGD 值得关注，不仅因为它具有历史意义，还因为它是一种需要专家管理的疾病。
