The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet 9, DK-2100 Copenhagen, Denmark.
Reprod Biomed Online. 2013 Mar;26(3):272-9. doi: 10.1016/j.rbmo.2012.12.001. Epub 2012 Dec 13.
This questionnaire study describes the fertility and ovarian function in 143 adult female cancer survivors with only one ovary due to cryopreservation of the other. The women were asked about their ovarian function (as defined by the presence of a spontaneous menstrual cycle), pregnancies and their outcome. The mean follow-up time was 58months after cryopreservation (range 24-129months). The risk of premature ovarian failure was high in the group of patients with leukaemia (13/15; 87%) but low in the breast cancer group (5/54; 9%). Fifty-seven women had actively tried to become pregnant after end of treatment; of these, 41 women obtained a total of 68 pregnancies resulting in 45 live births and five ongoing pregnancies, 15 spontaneous abortions, one ectopic pregnancy and two elective abortions. In the remaining 86 women without a pregnancy wish, there had been five elective abortions. Ninety-three per cent of the pregnancies were after natural conception and only four cases were a result of fertility treatment. The overall risk of premature ovarian failure was low (22%). Patients who retain their ovarian function after treatment of a malignant disease have a good chance of becoming pregnant.
这项问卷调查研究描述了 143 名因冷冻保存另一侧卵巢而仅保留一侧卵巢的成年女性癌症幸存者的生育和卵巢功能。这些女性被问及她们的卵巢功能（定义为是否存在自发性月经周期）、妊娠及其结果。冷冻保存后平均随访时间为 58 个月（范围为 24-129 个月）。白血病患者组（13/15；87%）发生卵巢早衰的风险较高，但乳腺癌患者组（5/54；9%）较低。57 名女性在治疗结束后积极尝试怀孕；其中，41 名女性共怀孕 68 次，导致 45 名活产和 5 名持续妊娠，15 名自然流产，1 名异位妊娠和 2 名选择性流产。在其余 86 名没有怀孕愿望的女性中，有 5 例选择性流产。93%的妊娠是自然受孕，只有 4 例是通过生育治疗。总的来说，卵巢早衰的风险较低（22%）。在治疗恶性疾病后保留卵巢功能的患者有很大的怀孕机会。
