Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Neuron. 2013 Jan 23;77(2):243-50. doi: 10.1016/j.neuron.2012.01.034.
Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct excess hippocampal protein synthesis in the mouse model of FXS and can prevent one of the robust functional consequences of increased protein synthesis in FXS, epileptogenesis. These data suggest that lovastatin is potentially disease modifying and could be a viable prophylactic treatment for epileptogenesis in FXS.
脆性 X 综合征 (FXS) 的许多神经精神症状被认为是突触蛋白合成调节异常的结果。我们发现，洛伐他汀是一种广泛用于治疗高胆固醇的药物，可以纠正 FXS 小鼠模型中海马过度的蛋白合成，并可以预防 FXS 中蛋白合成增加的一种强大的功能后果，即癫痫发生。这些数据表明，洛伐他汀具有潜在的疾病修饰作用，可能是 FXS 癫痫发生的可行预防治疗方法。
