Neven P, De Muylder X, Van Belle Y, Vanderick G, De Muylder E
Department of Obstetrics and Gynaecology, Clinique Générale Saint-Jean, Bruxelles, Belgium.
Eur J Obstet Gynecol Reprod Biol. 1990 May-Jun;35(2-3):235-8. doi: 10.1016/0028-2243(90)90167-y.
In order to study the action of Tamoxifen upon the uterus, 16 breast cancer patients were prospectively evaluated by means of an hysteroscopy before Tamoxifen therapy and again after 6 to 36 months of treatment. The results show the occurrence of an endometrial polyp in four cases and of an adenocarcinoma in one case. Moreover, the previously atrophic mucosa became mildly proliferative in seven of the patients who were evaluated.
为研究他莫昔芬对子宫的作用，对16例乳腺癌患者在他莫昔芬治疗前进行宫腔镜检查，并在治疗6至36个月后再次进行检查，进行前瞻性评估。结果显示，4例出现子宫内膜息肉，1例出现腺癌。此外，在接受评估的患者中，有7例先前萎缩的黏膜变得轻度增生。
