Neurology Department, Virgen de la Luz Hospital, Cuenca, Spain; Universitat Internacional de Catalunya, Barcelona, Spain.
Neurology Department, Virgen de la Luz Hospital, Cuenca, Spain.
J Stroke Cerebrovasc Dis. 2014 Jan;23(1):140-7. doi: 10.1016/j.jstrokecerebrovasdis.2012.11.012. Epub 2013 Jan 22.
With the increase in life expectancy worldwide, changes in stroke subtypes and burden of stroke population are expected in both developing and developed countries. Prevalence of stroke subtypes and comorbidity in ischemic stroke patients was assessed in Brasilia, Brazil, and Cuenca, Spain.
This was an international (Brazilian-Spanish) cross-sectional study. Stroke subtypes were assessed by means of Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification. Modified Rankin scale was used to measure functional recovery and the Cumulative Illness Rating Scale for Geriatrics (CIRS-G) was used to assess comorbidity.
A total of 500 patients (mean age 66.2 ± 16.4 years; 48% female; 48.2% Spanish) were included in the study. Spanish patients were significantly older than Brazilian ones (76.4 ± 11.2 versus 56.7 ± 14.6 years; P < .0001). Prevalence of ischemic cardiopathy (20.3% versus 6.2%) and atrial fibrillation (25.7% versus 6.6%) was significantly higher in Spanish stroke patients, whereas they less frequently used tobacco (28.3% versus 52.9%); P less than .0001. Prevalence of stroke subtypes in Spanish and Brazilian stroke patients was: stroke of undetermined etiology (58.1% versus 32.4%), cardioembolism (24.5% versus 11.6%), lacunar infarct (11.6% versus 25.5%), atherothrombotic (3.7% versus 19.7%), and other causes (2.1% versus 10.8%); P less than .0001. The Spanish sample had a significantly higher frequency of comorbidities. The CIRS-G total score and CIRS-G mean number of affected organs significantly increased with age, and correlated with the level of functional dependence as measured by Rankin scale (rS = 0.50; P = .0005).
Spanish stroke people had a higher frequency of comorbid conditions, atrial fibrillation, and cardioembolism and these facts were associated with age. Atherothrombotic and lacunar strokes were more common in the younger Brazilian stroke population.
随着全球预期寿命的延长，发展中国家和发达国家的中风类型和中风人群负担预计都将发生变化。本研究在巴西巴西利亚和西班牙昆卡评估了缺血性中风患者的中风类型和合并症。
这是一项国际（巴西-西班牙）横断面研究。采用组织型纤溶酶原激活剂治疗急性缺血性卒中试验（TOAST）分类评估中风类型。采用改良Rankin 量表评估功能恢复情况，采用老年 Cumulative Illness Rating Scale（CIRS-G）评估合并症。
共纳入 500 例患者（平均年龄 66.2 ± 16.4 岁；48%为女性；48.2%为西班牙人）。西班牙患者明显比巴西患者年龄大（76.4 ± 11.2 岁比 56.7 ± 14.6 岁；P<0.0001）。西班牙中风患者缺血性心脏病（20.3%比 6.2%）和心房颤动（25.7%比 6.6%）的患病率明显更高，而吸烟的比例较低（28.3%比 52.9%）；P<0.0001。西班牙和巴西中风患者的中风类型如下：病因不明的中风（58.1%比 32.4%）、心源性栓塞（24.5%比 11.6%）、腔隙性梗死（11.6%比 25.5%）、动脉粥样硬化血栓形成（3.7%比 19.7%）和其他原因（2.1%比 10.8%）；P<0.0001。西班牙样本的合并症发生率明显较高。CIRS-G 总分和 CIRS-G 受影响器官数均值随年龄增长而增加，与 Rankin 量表评估的功能依赖程度相关（rS=0.50；P=0.0005）。
西班牙中风患者合并症、心房颤动和心源性栓塞的频率较高，这些与年龄相关。年轻的巴西中风患者中更常见动脉粥样硬化血栓形成和腔隙性中风。
