Pulkkinen M O, Eskola J, Kleimola V, Simberg N H, Thuren T
Department of Obstetrics and Gynecology, University of Turku, Finland.
Gynecol Obstet Invest. 1990;29(2):104-7. doi: 10.1159/000293312.
The serum pancreatic and catalytic phospholipase A2 level (PLA2) in human pregnancy is normal, and the increase of pancreatic enzyme before delivery is small. In patients with pruritus associated with obstetric hepatosis maternal serum had a slightly lower pancreatic PLA2 level if the cholic acid level was higher. Umbilical cord blood has twice as much pancreatic PLA2 as maternal blood. If the enzyme concentration was very high, pregnancies were postterm and the newborns had low Apgar scores. Amniotic fluid contains these enzymes, but there is no change in the enzymes during the course of pregnancy. The amount of pancreatic enzyme was not reflected in catalytic activity. A very high PLA2 activity was observed in 1 patient with suspected amniotic fluid embolism and in the meconium, but low in the first urine of neonates.
人类妊娠期间血清胰腺和催化性磷脂酶A2水平（PLA2）正常，分娩前胰腺酶升高幅度较小。在与产科肝病相关的瘙痒症患者中，如果胆酸水平较高，母体血清中的胰腺PLA2水平略低。脐血中的胰腺PLA2含量是母血的两倍。如果酶浓度非常高，则妊娠为过期妊娠，新生儿阿氏评分较低。羊水含有这些酶，但在妊娠过程中酶没有变化。胰腺酶的量未反映在催化活性中。在1例疑似羊水栓塞患者的羊水和胎粪中观察到非常高的PLA2活性，但新生儿首次尿液中的活性较低。
