Chen Zhiye, Li Jinfeng, Liu Mengyu, Ma Lin
Department of Radiology, General Hospital of PLA, Beijing, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2013 Jan;33(1):74-9.
To investigate the age-related changes in resting functional connectivity of the marginal division (MrD) of the neostriatum in healthy adults detected using resting-state functional magnetic resonance imaging (rs-fMRI).
Forty-four healthy volunteers aged between 22 and 44 years (mean 30.36∓6.31 years) and 20 elderly volunteers aged between 48-83 years (mean 61.4∓10.25 years) underwent conventional MRI, 3D structural MRI and rs-fMRI. MrD was defined manually on the structural images for computation of the functional connectivity maps. The single group data were analyzed with independent sample t test, and the data of the two-group were examined by analysis of covariance with gender as the covariance.
In the young volunteers, the brain regions of functional connectivity related with the MrD were located in bilateral middle cingulate gyri, putamen, thalamus and amygdala, as compared with the brain regions of the bilateral putamen, thalamus, amygdala, insular cortex, rolandic operculum and right supramarginal gyrus in the elderly volunteers. Compared with the young volunteers, the elderly volunteers showed decreased functional connectivity related with the MrD in the bilateral middle cingulate gyri, parahippocampal gyri and left hippocampus.
An increased age is associated with alterations in the functional connectivity related with the MrD in healthy adults.
采用静息态功能磁共振成像（rs-fMRI）研究健康成年人新纹状体边缘区（MrD）静息功能连接的年龄相关变化。
44名年龄在22至44岁之间（平均30.36±6.31岁）的健康志愿者和20名年龄在48至83岁之间（平均61.4±10.25岁）的老年志愿者接受了传统MRI、三维结构MRI和rs-fMRI检查。在结构图像上手动定义MrD，以计算功能连接图。单组数据采用独立样本t检验进行分析，两组数据以性别作为协变量进行协方差分析。
与老年志愿者双侧壳核、丘脑、杏仁核、岛叶皮质、中央沟盖和右侧缘上回的脑区相比，年轻志愿者中与MrD相关的功能连接脑区位于双侧中央扣带回、壳核、丘脑和杏仁核。与年轻志愿者相比，老年志愿者双侧中央扣带回、海马旁回和左侧海马中与MrD相关的功能连接降低。
年龄增长与健康成年人中与MrD相关的功能连接改变有关。
